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RAB11FIP5

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For Research Use Only. Not For Clinical Use.


Background

Rab effector involved in protein trafficking from apical recycling endosomes to the apical plasma membrane. Involved in insulin granule exocytosis. May regulate V-ATPase intracellular transport in response to extracellular acidosis.
Protein class

Plasma proteins

Predicted location

Intracellular

Single cell type specificity

Cell type enhanced (Late spermatids, Early spermatids)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Cell line enhanced (HDLM-2)

Interaction

Interacts with RAB11FIP4 (PubMed:11278501, PubMed:12470645). Interacts with NAPG (PubMed:11278501). Interacts with RO60 (PubMed:10545525). Interacts with RAB11A that has been activated by GTP binding (PubMed:11163216). (Microbial infection) Interacts with Kaposi's sarcoma-associated herpesvirus/HHV-8 protein ORF45; this interaction results in the lysosomal degradation of ORF45 and the inhibition of viral particle release.

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