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RAB18

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For Research Use Only. Not For Clinical Use.


Background

The protein encoded by this gene is a member of a family of Ras-related small GTPases that regulate membrane trafficking in organelles and transport vesicles. Knockdown studies is zebrafish suggest that this protein may have a role in eye and brain development. Mutations in this gene are associated with Warburg micro syndrome type 3. Alternatively spliced transcript variants have been found for this gene.
Protein class

Cancer-related genes, Disease related genes, Human disease related genes

Predicted location

Intracellular, Membrane (different isoforms)

Single cell type specificity

Low cell type specificity

Immune cell specificity

Low immune cell specificity

Cell line specificity

Low cell line specificity

Interaction

Interacts (in GTP-bound form) with ZFYVE1 (PubMed:31293035, PubMed:30970241). Interacts with ZW10 and this interaction is enhanced in the presence of ZFYVE1 (PubMed:30970241). Interacts with BSCL2 (PubMed:30970241). (Microbial infection) Interacts with Hepatitis C virus (HCV) non-structural protein 5A; this interaction may promote the association of NS5A and other viral replicase components with lipid droplets.

Molecular function

Developmental protein

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