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RAB39B
This gene encodes a member of the Rab family of proteins. Rab proteins are small GTPases that are involved in vesicular trafficking. Mutations in this gene are associated with X-linked mental retardation.
Protein class
Disease related genes, Human disease related genes, Plasma proteins
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Bipolar cells, Muller glia cells, Oligodendrocytes, Horizontal cells, Inhibitory neurons)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Cell line enhanced (Daudi, Karpas-707, U-266/70, U-266/84)
Interaction
Interacts (in GTP-bound form) with PICK1 (via PDZ domain); a PICK1 homodimer may allow simultaneous association of RAB39B and GRIA2 to PICK1 which is involved in GRIA2 trafficking. Interacts with isoform c of RASSF1; the interaction is strong (By similarity). Interacts with isoform a of RASSF1; the interaction is weak (By similarity). Interacts with the DLG4/PSD-95 (By similarity).
More Types Infomation
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- Derivation: Phage display library screening
- Species Reactivity: Human
- Type: IgG
- Application: WB, ICC/IF, FC
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- Species Reactivity: Human
- Application: WB
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For Research Use Only. Not For Clinical Use.