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RAB3B
Loading...Anti-RAB3B Products
- Anti-RAB3B Immunohistochemistry Kit (VS-0525-XY5925)
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- Species Reactivity: Human
- Target: RAB3B
- Application: IHC
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For Research Use Only. Not For Clinical Use.
Background
Enables GDP binding activity; GTPase activity; and myosin V binding activity. Involved in several processes, including positive regulation of dopamine uptake involved in synaptic transmission; regulation of synaptic vesicle cycle; and regulation of vesicle size. Located in perinuclear region of cytoplasm and vesicle. Is active in dopaminergic synapse. Is anchored component of synaptic vesicle membrane.
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Enteroendocrine cells, Alveolar cells type 1, Alveolar cells type 2, Pancreatic endocrine cells)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enhanced (BJ, BJ hTERT+, fHDF/TERT166, TIME)
Interaction
Interacts with RIMS1, RIMS2, RPH3A and RPH3AL. The GTP-bound form interacts with GAS8/DRC4 (via coiled-coil domains) (By similarity). Interacts with GDI2, CHM and CHML; phosphorylation at Thr-86 disrupts these interactions (PubMed:29125462). Interacts with MADD (via uDENN domain); the GTP-bound form is preferred for interaction (By similarity).
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