Intracellular
Cell type enhanced (Spermatocytes, Early spermatids)
Low immune cell specificity
Cell line enhanced (Daudi)
Part of a DNA-binding complex containing RFC2, RFC3, RFC4 and RFC5. Interacts with RAD1 and RAD9 within the RAD1-RAD9-HUS1 complex. Interacts with RAD9B, POLE, SNU13 and MCM7. DNA damage promotes interaction with ATR or ATM and disrupts interaction with the RAD1-RAD9-HUS1 complex.
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For Research Use Only. Not For Clinical Use.