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RASAL2
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For Research Use Only. Not For Clinical Use.
Background
This gene encodes a protein that contains the GAP-related domain (GRD), a characteristic domain of GTPase-activating proteins (GAPs). GAPs function as activators of Ras superfamily of small GTPases. The protein encoded by this gene is able to complement the defective RasGAP function in a yeast system. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
Protein class
Plasma proteins, RAS pathway related proteins
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Excitatory neurons, Inhibitory neurons, Microglial cells)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enhanced (hTERT-HME1)
Molecular function
GTPase activation
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