Anti-RCAN1 Products

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For Research Use Only. Not For Clinical Use.

Creative Biolabs understands the complexities of neuroscience and Down syndrome research, which is why we offer you the highly specific anti-RCAN1 recombinant antibodies. Regulator of Calcineurin 1 (RCAN1) is the endogenous inhibitor of the phosphatase calcineurin and a key modulator of this signaling pathway. Our high-quality antibodies are the right tools to explore the pathogenesis of Down syndrome and Alzheimer's disease, as well as the feedback loops that fine-tune NFAT signaling.

RCAN1: The Endogenous Brake on Calcineurin Signaling

Regulator of Calcineurin 1 (RCAN1), also known as DSC1, is a protein that in humans is encoded by the RCAN1 gene. The RCAN1 gene is on chromosome 21 in the Down syndrome critical region. RCAN1 is a potent endogenous feedback inhibitor of calcineurin. RCAN1 directly binds to the catalytic subunit of calcineurin and inhibits its phosphatase activity, thus preventing the dephosphorylation of NFAT and other substrates of calcineurin. RCAN1 expression is itself induced by calcineurin/NFAT signaling, and this constitutes a negative feedback loop. The chronic overexpression of RCAN1 by trisomy 21 is thought to underlie many features of Down syndrome, such as intellectual disability and early-onset Alzheimer's disease.

Alternative Names

CSP1; DSC1; RCN1; DSCR1; MCIP1; ADAPT78

Background

The protein encoded by this gene interacts with calcineurin A and inhibits calcineurin-dependent signaling pathways, which may play a role in central nervous system development. This gene is located in the minimal candidate region for the Down syndrome phenotype, and it is overexpressed in the brain of Down syndrome fetuses. Chronic overexpression of this gene may lead to neurofibrillary tangles, such as those seen in Alzheimer disease. Alternative splicing results in multiple transcript variants.

Anti-RCAN1 rAb Products

Creative Biolabs' anti-RCAN1 recombinant antibodies have been engineered for high specificity and performance. They have been thoroughly validated to detect the RCAN1 protein and its isoforms accurately. Our antibodies are optimized for applications like Western Blot to evaluate overexpression or IHC to visualize its distribution in the brain and offer the reliability you need for your neuroscience research.

Table 1. Featured anti-RCAN1 recombinant antibody products at Creative Biolabs.

Customer Reviews

rAb Production

Creative Biolabs has invested in the latest antibody production platforms to support the unique requirements of neuroscience research. Our anti-RCAN1 recombinant antibodies are expressed in systems that are optimized for high fidelity recognition of the native protein, to provide you with a highly specific and active tool for your most demanding experiments.

Featured Anti-RCAN1 Recombinant Antibody Production Platforms
Fig.1 Milligram-scale anti-RCAN1 recombinant antibody production.

Fig.2 Gram-scale anti-RCAN1 recombinant antibody production.

rAb Modalities

Creative Biolabs is committed to supporting the power of scientific discovery with a portfolio of flexible antibody solutions. Our anti-RCAN1 recombinant antibodies are available in a range of customizable formats to meet diverse experimental needs. Empowering researchers everywhere to study this critical inhibitory protein.

Fig.3 Full-length anti-RCAN1 recombinant antibody production and modalities.

Probe the intricacies of calcineurin dysregulation in disease with Creative Biolabs' anti-RCAN1 recombinant antibodies. Our portfolio of reagents has been subjected to the rigorous validation and lot-to-lot consistency required to study this important protein in Down syndrome and neurodegeneration. Trust us to help provide a strong foundation for your research. Contact our scientific team today.