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RGS17
Anti-RGS17 Recombinant Antibody Products
- Chicken Anti-RGS17 Polyclonal IgY (BRD-0499MZ)
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- Species Reactivity: Human, Mouse, Rat
- Type: Chicken antibody
- Application: WB
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For Research Use Only. Not For Clinical Use.
This gene encodes a member of the regulator of G-protein signaling family. This protein contains a conserved, 120 amino acid motif called the RGS domain and a cysteine-rich region. The protein attenuates the signaling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. [provided by RefSeq, Jul 2008]
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Oligodendrocyte precursor cells, Inhibitory neurons, Excitatory neurons, Enteroendocrine cells)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enhanced (ASC TERT1, hTERT-HME1, LHCN-M2, RH-30, U-87 MG)
Interaction
Interacts with GNAI1 and GNAQ (PubMed:18434541). Interacts with GNAZ and GNAI2. Interacts with OPRM1. Forms a complex with mu-opioid receptors and G(alpha)z/i2 subunits, including GNAZ and GNAI2; the formation of this complex results in mu-opioid receptor desensitization (By similarity). Interacts with HINT1 (By similarity).
Molecular function
GTPase activation, Signal transduction inhibitor
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