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RIPK4

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For Research Use Only. Not For Clinical Use.


Background

The protein encoded by this gene is a serine/threonine protein kinase that interacts with protein kinase C-delta. The encoded protein can also activate NFkappaB and is required for keratinocyte differentiation. This kinase undergoes autophosphorylation. [provided by RefSeq, Jul 2008]
Protein class

Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets

Predicted location

Intracellular

Single cell type specificity

Cell type enhanced (Glandular and luminal cells, Endometrial ciliated cells, Squamous epithelial cells, Gastric mucus-secreting cells, Basal squamous epithelial cells)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Cell line enhanced (CAPAN-2, GAMG, HaCaT, hTCEpi, RPTEC TERT1, RT4)

Interaction

Interacts with PRKCB (By similarity). Interacts with TRAF1, TRAF2, TRAF3 and TRAF5. Interacts with BIRC2/c-IAP1, BIRC3/c-IAP2 and XIAP/BIRC4.

Molecular function

Kinase, Receptor, Serine/threonine-protein kinase, Transferase

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