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RNASEH2B
Anti-RNASEH2B Recombinant Antibody Products
- Anti-RNASEH2B Immunohistochemistry Kit (VS-0325-XY1926)
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- Species Reactivity: Human, Mouse
- Target: RNASEH2B
- Application: IHC
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For Research Use Only. Not For Clinical Use.
RNase H2 is composed of a single catalytic subunit (A) and two non-catalytic subunits (B and C) and specifically degrades the RNA of RNA:DNA hybrids. The protein encoded by this gene is the non-catalytic B subunit of RNase H2, which is thought to play a role in DNA replication. Multiple transcript variants encoding different isoforms have been found for this gene. Defects in this gene are a cause of Aicardi-Goutieres syndrome type 2 (AGS2).
Protein class
Disease related genes, Human disease related genes
Predicted location
Intracellular
Single cell type specificity
Low cell type specificity
Immune cell specificity
Low immune cell specificity
Cell line specificity
Cell line enhanced (MOLT-4, NB-4, REH, THP-1)
Interaction
The RNase H2 complex is a heterotrimer composed of the catalytic subunit RNASEH2A and the non-catalytic subunits RNASEH2B and RNASEH2C.
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