RNF139

Formats

Anti-RNF139 Recombinant Antibody Products

Recombinant Mouse Anti-Human RNF139 Antibody (MOB-1294MZ)
- Species Reactivity: Human
- Type: Mouse antibody
- Application: IHC-P, WB
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For Research Use Only. Not For Clinical Use.

Protein class

Disease related genes, Enzymes, Metabolic proteins, Potential drug targets

Predicted location

Membrane

Single cell type specificity

Group enriched (Late spermatids, Early spermatids)

Immune cell specificity

Low immune cell specificity

Cell line specificity

Low cell line specificity

Interaction

Interacts with MHC class I and HM13 (PubMed:19720873, PubMed:25239945). Interacts with VHL (PubMed:12032852). Component of SCAP-SREBP complex composed of SREBF2, SCAP and RNF139; the complex hampers the interaction between SCAP and SEC24B, thereby reducing SREBF2 proteolytic processing (PubMed:19706601). Interacts with SREBF2 (via C-terminal domain) (PubMed:19706601). Interacts with SCAP; the interaction inhibits the interaction of SCAP with SEC24B and hampering the ER to Golgi transport of the SCAP-SREBP complex (PubMed:19706601). Interacts with SEC24B (PubMed:19706601). Interacts with INSIG1 and INSIG2 (PubMed:20068067, PubMed:22143767). Interacts with EIF3F and EIF3H; the interaction leads to protein translation inhibitions in a ubiquitination-dependent manner (PubMed:20068067). Interacts with XBP1 isoform 1; the interaction induces ubiquitination and degradation of XBP1 isoform 1 (PubMed:25239945). Interacts with AUP1, AMFR and UBE2G2; interaction with AUP1 facilitates interaction of RNF139 with ubiquitin-conjugating enzyme UBE2G2 and ubiquitin ligase AMFR/gp78, leading to sterol-induced ubiquitination of HMGCR and its subsequent proteasomal degradation (PubMed:23223569).

Molecular function

Receptor, Transferase

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