RORC
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- Derivation: Phage display library screening
- Species Reactivity: Human
- Type: IgG
- Application: FC, IP, WB
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- Anti-RORC Immunohistochemistry Kit (VS-0525-XY6181)
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- Species Reactivity: Human
- Target: RORC
- Application: IHC
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- Mouse Anti-RORC Recombinant Antibody (VS-1225-YC9) (VS-1225-YC9)
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- Species Reactivity: Human, Mouse
- Type: Mouse IgG2b
- Application: WB
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For Research Use Only. Not For Clinical Use.
Background
The protein encoded by this gene is a DNA-binding transcription factor and is a member of the NR1 subfamily of nuclear hormone receptors. The specific functions of this protein are not known; however, studies of a similar gene in mice have shown that this gene may be essential for lymphoid organogenesis and may play an important regulatory role in thymopoiesis. In addition, studies in mice suggest that the protein encoded by this gene may inhibit the expression of Fas ligand and IL2.
Protein class
Disease related genes, Human disease related genes, Nuclear receptors, Transcription factors
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Hepatocytes, Distal tubular cells, Proximal enterocytes)
Immune cell specificity
Immune cell enriched (MAIT T-cell)
Cell line specificity
Cell line enhanced (HDLM-2, Karpas-707, MOLT-4, RPMI-8226, SK-BR-3, T-47d)
Interaction
Interacts (via AF-2 motif) with the coactivator NCOA2 (via LXXLL motif) (PubMed:20211758). Interacts with the corepressor NCOR1 (By similarity). Interacts with CRY1 (PubMed:22170608). Interacts (via AF-2 motif) with the coactivators NCOA1 and PPARGC1A (via LXXLL motif) (By similarity). Interacts (via AF-2 motif) with PROX1 (By similarity). Interacts with FOXP3 (PubMed:18368049). Interacts with NR0B2 (By similarity).
Molecular function
Activator, Developmental protein, DNA-binding, Receptor
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