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    RTN1

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    For Research Use Only. Not For Clinical Use.


    Background

    This gene belongs to the family of reticulon encoding genes. Reticulons are associated with the endoplasmic reticulum, and are involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells. This gene is considered to be a specific marker for neurological diseases and cancer, and is a potential molecular target for therapy. Alternative splicing results in multiple transcript variants.
    Protein class

    Plasma proteins, Transporters

    Predicted location

    Membrane

    Single cell type specificity

    Cell type enhanced (Excitatory neurons, Inhibitory neurons, Oligodendrocytes, Horizontal cells, Oligodendrocyte precursor cells)

    Immune cell specificity

    Group enriched (myeloid DC, intermediate monocyte, classical monocyte)

    Cell line specificity

    Group enriched (HEL, SCLC-21H, SH-SY5Y)

    Interaction

    Interacts with NDRG1 (PubMed:15922294). Interacts with BACE1 (PubMed:15286784). [Isoform RTN1-A]: Interacts with TMEM33 (PubMed:25612671). [Isoform RTN1-C]: Interacts with UGCG; regulates the ceramide glucosyltransferase activity of UGCG (PubMed:12873973).

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