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SAGE1

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For Research Use Only. Not For Clinical Use.


Background

This gene belongs to a class of genes that are activated in tumors. These genes are expressed in tumors of different histologic types but not in normal tissues, except for spermatogenic cells and, for some, placenta. The proteins encoded by these genes appear to be strictly tumor specific, and hence may be excellent sources of antigens for cancer immunotherapy. This gene is expressed in sarcomas.
Predicted location

Intracellular

Single cell type specificity

Cell type enriched (Spermatogonia)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Cell line enhanced (AN3-CA, K-562, Karpas-707, U-2 OS, U-266/70, U-266/84)

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