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SECTM1
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For Research Use Only. Not For Clinical Use.
Background
Secreted and transmembrane protein 1 is a protein that in humans is encoded by the SECTM1 gene. SECTM1 is a 27 kDa type I transmembrane protein whose soluble form is a ligand for CD7. SECTM1 is expressed by a number of normal cell types, including neutrophils, dendritic cells and epithelial cells. It is also highly expressed by breast and prostate cancer cell lines, and by some myeloid leukemias.
Predicted location
Membrane, Secreted (different isoforms)
Single cell type specificity
Cell type enhanced (Distal enterocytes, Proximal enterocytes, Kupffer cells, Paneth cells, Macrophages)
Immune cell specificity
Immune cell enhanced (neutrophil)
Cell line specificity
Cell line enhanced (ASC TERT1, BJ hTERT+, BJ hTERT+ SV40 Large T+, BJ hTERT+ SV40 Large T+ RasG12V, PC-3, SiHa, SK-BR-3, U-2197)
Interaction
Interacts with CD7.
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