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SFTPA1

In presence of calcium ions, it binds to surfactant phospholipids and contributes to lower the surface tension at the air-liquid interface in the alveoli of the mammalian lung and is essential for normal respiration
Protein class

Disease related genes, Human disease related genes

Predicted location

Secreted

Single cell type specificity

Cell type enriched (Alveolar cells type 2)

Immune cell specificity

Immune cell enriched (plasmacytoid DC)

Cell line specificity

Cell line enriched (RPMI-8226)

Interaction

Oligomeric complex of 6 set of homotrimers. (Microbial infection) Binds M. bovis cell surface protein Apa via its glycosylated sites; probably also recognizes other bacterial moieties. (Microbial infection) Binds to the S. aureus extracellular adherence protein, Eap, thereby enhancing phagocytosis and killing of S. aureus by alveolar macrophages.

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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