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SGPL1

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For Research Use Only. Not For Clinical Use.


Background

SGPL1, or Sphingosine-1-phosphate lyase 1, is an enzyme that irreversibly cleaves sphingosine-1-phosphate (S1P) into ethanolamine phosphate and hexadecenal. SGPL1 is the committed step in S1P degradation, regulating the cellular levels of this potent lipid signaling molecule, which is involved in diverse processes like immunity, cell growth, and angiogenesis.
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