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For Research Use Only. Not For Clinical Use.
Intracellular
Cell type enhanced (Oligodendrocytes, Oligodendrocyte precursor cells)
Not detected in immune cells
Cell line enhanced (ASC diff, ASC TERT1, HSkMC)
Interacts with ADAM12. Isoform 4 and isoform 5 (but not isoform 1 and isoform 2) interact with ADAM9, ADAM10, ADAM15 and ADAM17. Interacts with SH3GL1 SH3 domain. Interacts via SH3 3 and SH3 4 or SH3 4 and SH3 5 domains with SOS2. Probably forms a trimeric complex with SH3GL1 and SOS2. Interacts with SH3YL1 (By similarity).