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SIK2

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For Research Use Only. Not For Clinical Use.


Background

Phosphorylates Ser-794 of IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction. Inhibits CREB activity by phosphorylating and repressing TORCs, the CREB-specific coactivators.
Protein class

Enzymes, Metabolic proteins

Predicted location

Membrane

Single cell type specificity

Cell type enhanced (Excitatory neurons, Oligodendrocytes, Inhibitory neurons, Astrocytes)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Cell line enhanced (ASC diff)

Interaction

Interacts with and phosphorylates TORC2/CRTC2.

Molecular function

Kinase, Serine/threonine-protein kinase, Transferase

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