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SIX3
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- Recombinant Mouse Anti-Human SIX3 Antibody (MOB-1780MZ)
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- Species Reactivity: Human
- Type: Mouse antibody
- Application: WB
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For Research Use Only. Not For Clinical Use.
Protein class
Disease related genes, Human disease related genes, Transcription factors
Predicted location
Intracellular
Single cell type specificity
Group enriched (Muller glia cells, Bipolar cells, Horizontal cells)
Immune cell specificity
Immune cell enhanced (basophil)
Cell line specificity
Group enriched (hTERT-RPE1, SCLC-21H, SH-SY5Y)
Interaction
Interacts with EYA4; translocates EYA4 from the cytoplasm to the nucleus and promotes activation of their target genes (By similarity). Interacts with MTA1 and HDAC2; represses its own transcription (By similarity). Interacts with MTA1; facilitates the binding of SIX3 to the core DNA motif of SIX3 promoter (By similarity). Interacts with EYA1; promotes EYA1 translocation to the nucleus (By similarity). Interacts with TLE1 and TLE5 (via Q domain); can act in combination with either TLE1 and/or TLE5 leading to transcriptional repression or activation, respectively. Interacts (via homeobox) with NR4A3; differentially regulates the transcriptional activities NR4A3. Interacts with GMNN. Interacts with TLE4.
Molecular function
Developmental protein, DNA-binding, Repressor
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