Intracellular
Cell type enhanced (dendritic cells, Kupffer cells, T-cells, Macrophages, NK-cells, Plasma cells, Hofbauer cells)
Low immune cell specificity
Cell line enhanced (HMC-1, JURKAT, Karpas-707, MOLT-4, U-266/84, U-937)
Interacts with EPHA2, VAV1, LCP2 and PDGFRB (By similarity). Homodimer. Homodimerization and interaction with phosphorylated CBL occurs via its C-terminal domain. Interacts with phosphorylated proteins ZAP70, CD3Z, SYK and LAT via its SH2 domain.
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For Research Use Only. Not For Clinical Use.