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For Research Use Only. Not For Clinical Use.
Disease related genes, Human disease related genes, Metabolic proteins, Potential drug targets, Transporters
Intracellular, Membrane (different isoforms)
Cell type enhanced (Astrocytes, Distal enterocytes, Proximal tubular cells, Cholangiocytes, Ductal cells)
Not detected in immune cells
Cell line enhanced (BJ, fHDF/TERT166, HBF TERT88, hTERT-RPE1, RPTEC TERT1, U-138 MG)
Homodimer (PubMed:29500354). Interacts with CA2/carbonic anhydrase 2 and CA4/carbonic anhydrase 4 which may regulate transporter activity (PubMed:12411514, PubMed:14567693, PubMed:15218065, PubMed:15563508). Isoform 1 but not isoform 2 interacts with AHCYL1 (via PEST domain when phosphorylated); the interaction increases SLC4A4 isoform 1 activity (PubMed:16769890). Interacts with AHCYL2 (By similarity).