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SOCS6
The protein encoded by this gene contains a SH2 domain and a CIS homolog domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by GM-CSF and EPO in hematopoietic cells. A high expression level of this gene was found in factor-independent chronic myelogenous leukemia (CML) and erythroleukemia (HEL) cell lines.
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Microglial cells)
Immune cell specificity
Immune cell enhanced (myeloid DC, classical monocyte)
Cell line specificity
Low cell line specificity
Interaction
Interacts with RBCK1. Interacts with phosphorylated IRS4 (By similarity). Interacts with PIM3 (By similarity). Interacts with KIT (phosphorylated).
Molecular function
Signal transduction inhibitor
More Types Infomation
- Recombinant Mouse Anti-Human SOCS6 Antibody (MOB-1971MZ)
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- Species Reactivity: Human
- Type: Mouse antibody
- Application: WB
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For Research Use Only. Not For Clinical Use.