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SOX3
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For Research Use Only. Not For Clinical Use.
Background
Transcription factor required during the formation of the hypothalamo-pituitary axis. May function as a switch in neuronal development. Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation. Required also within the pharyngeal epithelia for craniofacial morphogenesis. Controls a genetic switch in male development. Is necessary for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells (By similarity).
Protein class
Disease related genes, Human disease related genes, Transcription factors
Predicted location
Intracellular
Single cell type specificity
Group enriched (Muller glia cells, Skeletal myocytes, Astrocytes, Oligodendrocyte precursor cells, Spermatogonia)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enhanced (AF22, HEK93, NTERA-2, SuSa)
Interaction
Interacts with SOX2 and FGFR1.
Molecular function
Developmental protein, DNA-binding
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