SPRY4

Recombinant Antibody Products Formats

Anti-SPRY4 Recombinant Antibody Products

Recombinant Rabbit Anti-SPRY4 Antibody (clone R01-6K5) (VS3-FY1384)
- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, IHC-Fr, IHC-P, ICC, IF, IP
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Hi-Affi™ Recombinant Rabbit Anti-SPRY4 Monoclonal Antibody (DS3397AB) (MOR-3397)
- Derivation: Phage display library screening
- Species Reactivity: Mouse, Rat, Human
- Type: IgG
- Application: FC, IP, WB, ICC/IF
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For Research Use Only. Not For Clinical Use.

This gene encodes a member of a family of cysteine- and proline-rich proteins. The encoded protein is an inhibitor of the receptor-transduced mitogen-activated protein kinase (MAPK) signaling pathway. Activity of this protein impairs the formation of active GTP-RAS. Nucleotide variation in this gene has been associated with hypogonadotropic hypogonadism 17 with or without anosmia. Alternative splicing results in a multiple transcript variants. [provided by RefSeq, Jun 2014]

Protein class

Disease related genes, Human disease related genes

Predicted location

Intracellular, Membrane (different isoforms)

Single cell type specificity

Cell type enhanced (Oligodendrocyte precursor cells, Alveolar cells type 2, Adipocytes, Hepatic stellate cells, Endothelial cells)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Cell line enhanced (AN3-CA, WM-115)

Interaction

Interacts (via C-terminus) with TESK1 (via both C- and N-termini); the interaction inhibits TESK1 kinase activity (PubMed:12027893, PubMed:15584898). Interacts with RAF1 (PubMed:12717443). Interacts with CAV1 (via C-terminus) (By similarity).

Molecular function

Developmental protein

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