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STOM
Anti-STOM Recombinant Antibody Products
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For Research Use Only. Not For Clinical Use.
This gene encodes a member of a highly conserved family of integral membrane proteins. The encoded protein localizes to the cell membrane of red blood cells and other cell types, where it may regulate ion channels and transporters. Loss of localization of the encoded protein is associated with hereditary stomatocytosis, a form of hemolytic anemia. There is a pseudogene for this gene on chromosome 6. Alternative splicing results in multiple transcript variants.
Protein class
Plasma proteins, Transporters
Predicted location
Membrane
Single cell type specificity
Cell type enhanced (Erythroid cells, Adipocytes, Hepatocytes)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Cell line enhanced (ASC diff, hTCEpi)
Interaction
Homodimer and higher order homooligomer. The homodimer is banana-shaped. Interacts with ASIC1, ASIC2 and ASIC3 (By similarity). Interacts with LANCL1. Interacts with SLC2A1 and SLC4A1. Identified in large complexes with SLC40A1, SLC14A1, SLC29A1 and AQP1. Interacts with STOML1; may redistribute STOM from the plasma membrane to late endosomes.
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