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SULF1

This gene encodes an extracellular heparan sulfate endosulfatase. The encoded enzyme selectively removes 6-O-sulfate groups from heparan sulfate chains of heparan sulfate proteoglycans (HSPGs). The enzyme is secreted through the Golgi and is subsequently localized to the cell surface. The expression of this gene may be down-regulated in several types of cancer, including hepatocellular (HCC), ovarian and breast cancers. Alternative splicing results in multiple transcript variants.
Predicted location

Intracellular

Single cell type specificity

Cell type enhanced (Early spermatids, Muller glia cells, Late spermatids, Inhibitory neurons, Fibroblasts)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Cell line enhanced (BJ, BJ hTERT+, fHDF/TERT166, U-2197, WM-115)

Molecular function

Hydrolase

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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