SV2A
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For Research Use Only. Not For Clinical Use.
Background
Protein class
FDA approved drug targets
Predicted location
Membrane
Single cell type specificity
Cell type enhanced (Bipolar cells, Inhibitory neurons, Horizontal cells, Excitatory neurons)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enhanced (NTERA-2)
Interaction
Interacts with SYT1/synaptotagmin-1 in a calcium-dependent manner. Binds the adapter protein complex AP-2 (By similarity). (Microbial infection) Interacts with C. botulinum neurotoxin type A2 (BoNT/A, botA) (PubMed:29649119). Interaction is improved by glycosylation of SV2 (PubMed:29649119).
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