Src-family Tyrosine Kinase

The Src-family Protein Tyrosine Kinases (SFKs) represent a crucial and highly conserved family of non-receptor tyrosine kinases (NRTKs) that function as pivotal intracellular signaling molecules. Named after their founding member, Src (the first identified proto-oncogene), this family plays a central role in relaying signals from a vast array of cell surface receptors - including receptor tyrosine kinases (RTKs), G protein-coupled receptors (GPCRs), integrins, cytokine receptors, and immune receptors (like TCRs and BCRs) - to numerous downstream effector pathways. Their ubiquitous expression in various cell types and involvement in almost every aspect of cellular behavior underscore their profound biological importance.