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TBL1X

Anti-TBL1X Products
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG2b
- Application: WB, ICC
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- Species Reactivity: Human
- Type: Human Fab
- Application: IP, IF, ELISA, IP-MS
- Mouse Anti-TBL1X Monoclonal Antibody (VS7-0425-WR951) (VS7-0425-WR951)
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- Species Reactivity: Human, Monkey
- Type: Mouse IgG
- Application: WB, ELISA
- Anti-TBL1X Immunohistochemistry Kit (VS-0525-XY7110)
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- Species Reactivity: Human
- Target: TBL1X
- Application: IHC
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For Research Use Only. Not For Clinical Use.
Background
The protein encoded by this gene has sequence similarity with members of the WD40 repeat-containing protein family. The WD40 group is a large family of proteins, which appear to have a regulatory function. It is believed that the WD40 repeats mediate protein-protein interactions and members of the family are involved in signal transduction, RNA processing, gene regulation, vesicular trafficking, cytoskeletal assembly and may play a role in the control of cytotypic differentiation. This encoded protein is found as a subunit in corepressor SMRT (silencing mediator for retinoid and thyroid receptors) complex along with histone deacetylase 3 protein. This gene is located adjacent to the ocular albinism gene and it is thought to be involved in the pathogenesis of the ocular albinism with late-onset sensorineural deafness phenotype. Four transcript variants encoding two different isoforms have been found for this gene. This gene is highly similar to the Y chromosome TBL1Y gene. [provided by RefSeq, Nov 2008]