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TERF2
This gene encodes a telomere specific protein, TERF2, which is a component of the telomere nucleoprotein complex. This protein is present at telomeres in metaphase of the cell cycle, is a second negative regulator of telomere length and plays a key role in the protective activity of telomeres. While having similar telomere binding activity and domain organization, TERF2 differs from TERF1 in that its N terminus is basic rather than acidic.
Predicted location
Intracellular
Single cell type specificity
Low cell type specificity
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
Homodimer. Component of the shelterin complex (telosome) composed of TERF1, TERF2, TINF2, TERF2IP/RAP1, ACD and POT1. Interacts with TERF2IP. Interacts with NBN. Interacts with SLX4/BTBD12. Interacts with DCLRE1B/Apollo and TERF2IP/RAP1; the interaction is direct.
Molecular function
DNA-binding
More Types Infomation
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- Species Reactivity: Human
- Type: Mouse antibody
- Application: FC, IHC-P, IP, WB
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- Derivation: Phage display library
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: ICC, IF, IHC-P, WB
- Mouse Anti-TERF2 Recombinant Antibody (clone 3H6B4) (VS3-XY1494)
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- Species Reactivity: Human
- Type: Mouse IgG1
- Application: ELISA, WB, IHC
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For Research Use Only. Not For Clinical Use.