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Target
Application
Host
Type
Species Reactivity
Conjugate
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TFR2

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For Research Use Only. Not For Clinical Use.


Background

This gene encodes a single-pass type II membrane protein, which is a member of the transferrin receptor-like family. This protein mediates cellular uptake of transferrin-bound iron, and may be involved in iron metabolism, hepatocyte function and erythrocyte differentiation. Mutations in this gene have been associated with hereditary hemochromatosis type III. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
Protein class

Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Plasma proteins, Transporters

Predicted location

Membrane

Single cell type specificity

Group enriched (Hepatocytes, Erythroid cells)

Immune cell specificity

Group enriched (basophil, eosinophil)

Cell line specificity

Group enriched (HEL, HMC-1, K-562)

Interaction

Homodimer.

Molecular function

Receptor

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