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THAP1
Anti-THAP1 Recombinant Antibody Products
- Mouse Anti-THAP1 Recombinant Antibody (clone 4A6C9) (VS3-XY1512)
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- Species Reactivity: Human
- Type: Mouse IgG1
- Application: ELISA, WB, FC
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- Mouse Anti-THAP1 Recombinant Antibody (clone 2F1B4) (VS7-0425-WR981)
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- Species Reactivity: Human
- Type: Mouse IgG1
- Application: FC
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- Mouse Anti-THAP1 Recombinant Antibody (clone 8D10C8) (VS7-0425-WR980)
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- Species Reactivity: Human
- Type: Mouse IgG1
- Application: ICC, FC
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For Research Use Only. Not For Clinical Use.
The protein encoded by this gene contains a THAP domain, a conserved DNA-binding domain. This protein colocalizes with the apoptosis response protein PAWR/PAR-4 in promyelocytic leukemia (PML) nuclear bodies, and functions as a proapoptotic factor that links PAWR to PML nuclear bodies. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
Protein class
Disease related genes, Human disease related genes, Transcription factors
Predicted location
Intracellular
Single cell type specificity
Low cell type specificity
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
Homodimer (PubMed:28299530). Interacts with PAWR. Component of a THAP1/THAP3-HCFC1-OGT complex that contains, either THAP1 or THAP3, HCFC1 and OGT. Interacts with OGT. Interacts (via the HBM) with HCFC1 (via the Kelch-repeat domain); the interaction recruits HCFC1 to the RRM1 promoter (PubMed:12717420, PubMed:20144952, PubMed:20200153).
Molecular function
DNA-binding
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