Plasma proteins, RAS pathway related proteins
Intracellular
Cell type enhanced (Inhibitory neurons, Suprabasal keratinocytes, Microglial cells, Oligodendrocytes, Oligodendrocyte precursor cells)
Group enriched (T-reg, non-classical monocyte, classical monocyte, naive CD4 T-cell, intermediate monocyte, memory CD4 T-cell, NK-cell, myeloid DC)
Cell line enhanced (BEWO, HEL, HMC-1, RT4, SCLC-21H)
Component of the Par polarity complex, composed of at least phosphorylated PRKCZ, PARD3 and TIAM1. Interacts with NTRK2; mediates the activation of RAC1 by BDNF. Interacts with MAPK8IP2 and CD44 (By similarity). Interacts with BAIAP2. Interacts with EPHA8; regulates clathrin-mediated endocytosis of EPHA8. Interacts with PARD3. Interacts (via PDZ domain) with CNTNAP4, SDC1 and SDC3 (via C-terminus).
Guanine-nucleotide releasing factor
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For Research Use Only. Not For Clinical Use.