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TLE6
Anti-TLE6 Recombinant Antibody Products
- Recombinant Mouse Anti-Human TLE6 Antibody (MOB-2345MZ)
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- Species Reactivity: Human
- Type: Mouse antibody
- Application: ELISA, WB
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- Rabbit Anti-TLE6 Polyclonal Antibody (MRO-2225-CN) (MRO-2225-CN)
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- Species Reactivity: Human, Mouse
- Type: Rabbit IgG
- Application: WB, IF, IHC, FC
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For Research Use Only. Not For Clinical Use.
This gene encodes a member of the Groucho/ transducin-like Enhancer of split family of transcriptional co-repressors. The encoded protein is a component of the mammalian subcortical maternal complex, which is required for preimplantation development. In mouse, knock out of this gene results in cleavage-stage embryonic arrest resulting from defective cytoplasmic F-actin meshwork formation and asymmetric cell division. In human, an allelic variant in this gene is associated with preimplantation embryonic lethality. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]
Protein class
Disease related genes, Human disease related genes
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Collecting duct cells, Extravillous trophoblasts, Syncytiotrophoblasts, Alveolar cells type 2, Distal tubular cells)
Immune cell specificity
Immune cell enhanced (NK-cell)
Cell line specificity
Cell line enhanced (BEWO, SK-BR-3, U-266/70, U-698, U-937)
Interaction
Homodimers (By similarity). Interacts with FOXG1/BF-1; the interaction inhibits TLE1 interaction with FOXG1/BF-1 (By similarity). Interacts with NFATC1 (By similarity). Interacts with PAX6 (By similarity). [Isoform 1]: Component of the subcortical maternal complex (SCMC), at least composed of NLRP5, KHDC3L, OOEP, and TLE6 isoform 1 (PubMed:26537248, PubMed:25542835). Within the complex, interacts with NLRP5, KHDC3L and OOEP (PubMed:26537248, PubMed:25542835). The SCMC may facilitate translocation of its components between the nuclear and cytoplasmic compartments (PubMed:25542835). As part of the SCMC interacts with the SCMC-associated protein ZBED3 (By similarity). As part of the SCMC interacts with the SCMC-associated protein NLRP4F (By similarity). As part of the SCMC interacts with the SCMC-associated protein CFL1/Cofilin-1 (By similarity).
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