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TLR1
Anti-TLR1 Recombinant Antibody Products
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: ELISA, FC, IF, IHC, FuncS
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- CytoStream™ Rat Anti-TLR1 Recombinant Antibody (VS-0225-XY211) (VS-0225-XY211)
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- Species Reactivity: Mouse
- Type: Rat IgG2a, kappa
- Application: FC
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For Research Use Only. Not For Clinical Use.
TLR1 is a member of the Toll - like receptor family, which is crucial for innate immunity. It is expressed on the cell surface of immune cells such as macrophages, dendritic cells, and neutrophils. TLR1 forms heterodimers with TLR2. This complex recognizes a variety of pathogen - associated molecular patterns (PAMPs), especially lipopeptides from bacteria. When activated, TLR1 - TLR2 heterodimers initiate signaling cascades through MyD88 adaptor protein, leading to the production of pro - inflammatory cytokines. These cytokines are essential for recruiting immune cells to the site of infection and initiating an effective immune response against pathogens.
Protein class
CD markers, Enzymes
Predicted location
Intracellular, Membrane (different isoforms)
Single cell type specificity
Cell type enhanced (Kupffer cells, Macrophages, Microglial cells, monocytes, B-cells, Hofbauer cells)
Immune cell specificity
Immune cell enhanced (neutrophil)
Cell line specificity
Cell line enhanced (Daudi, HUVEC TERT2, RPMI-8226, U-698, U-937)
Interaction
Interacts (via extracellular domain) with TLR2. TLR2 seems to exist in heterodimers with either TLR1 or TLR6 before stimulation by the ligand. The heterodimers form bigger oligomers in response to their corresponding ligands as well as further heterotypic associations with other receptors such as CD14 and/or CD36 (PubMed:16880211, PubMed:17889651). The activation cluster TLR2:TLR1:CD14 forms in response to triacylated lipopeptides (PubMed:16880211). Binds MYD88 (via TIR domain). Interacts with CNPY3 (By similarity).
Molecular function
Hydrolase, Receptor
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Related Signaling Pathways
NLR Signaling Pathway
TLR Signaling Pathway