TLR5
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Loading...- Rat Anti-Tlr5 Recombinant Antibody (NEUT-2042CQ) (NEUT-2042CQ)
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- Species Reactivity: Mouse
- Type: Rat IgG2a
- Application: Neut
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- Rabbit Anti-TLR5 Recombinant Antibody (clone JM10-88) (MRO-1502-CN)
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- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, IHC
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- Human Anti-TLR5 Recombinant Antibody (NEUT-2043CQ) (NEUT-2043CQ)
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- Species Reactivity: Human
- Type: Human IgA2
- Application: Neut, FC
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- Anti-Mouse TLR5 Immunohistochemistry Kit (VS-0525-XY7309)
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- Species Reactivity: Human, Mouse, Canine
- Target: TLR5
- Application: IHC
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- Anti-Rat TLR5 Immunohistochemistry Kit (VS-0525-XY7310)
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- Species Reactivity: Human, Rat
- Target: TLR5
- Application: IHC
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- Anti-TLR5 Immunohistochemistry Kit (VS-0525-XY7308)
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- Species Reactivity: Human
- Target: TLR5
- Application: IHC
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More Infomation
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For Research Use Only. Not For Clinical Use.
Background
Participates in the innate immune response to microbial agents. Mediates detection of bacterial flagellins. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.
Protein class
Disease related genes, Human disease related genes
Predicted location
Intracellular, Membrane (different isoforms)
Single cell type specificity
Cell type enhanced (Kupffer cells, Glandular and luminal cells, Microglial cells, Club cells)
Immune cell specificity
Group enriched (classical monocyte, intermediate monocyte, neutrophil, myeloid DC, non-classical monocyte)
Cell line specificity
Cell line enhanced (A-431, HaCaT, OE19, SK-BR-3, T-47d)
Interaction
Homodimer (PubMed:22173220). Interacts with MYD88 (via TIR domain) (PubMed:20855887). Interacts with TICAM1 (via TIR domain) (PubMed:20855887). Interacts with UNC93B1; this interaction is essential for proper TLR5 localization to the plasma membrane (PubMed:24778236).
Molecular function
Receptor
More Types Infomation
Related Signaling Pathways
NLR Signaling Pathway
TLR Signaling Pathway