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Anti-TLR8 Recombinant Antibody Products

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Anti-TLR8 ProductsTLR8Featured ProductsCreative Quality ControlCustomer ReviewsrAb ProductionrAb ModalitiesTLR8-Targeted Drug Information

Anti-TLR8 Products

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For Research Use Only. Not For Clinical Use.


Creative Biolabs proudly presents its cutting-edge anti-TLR8 recombinant antibody products, meticulously developed to empower global research and pharmaceutical development. These high-quality antibodies are engineered for unparalleled specificity and consistency, serving as indispensable tools for advanced immunological research, target validation, and the development of innovative therapeutic strategies.

TLR8: A Pivotal Target for Immunomodulatory Therapy

Toll-like Receptor 8 (TLR8) is a crucial innate immune receptor located within endosomes, primarily responsible for sensing single-stranded RNA (ssRNA) derived from pathogens. Extensive research has elucidated its structural configurations, including agonist- and antagonist-induced dimer formations, proposing detailed functional mechanisms. Given its critical role in antiviral immunity and modulating inflammatory responses, TLR8 represents a pivotal target for understanding disease pathogenesis and developing novel immunomodulatory and anti-infective therapies.

Alternative Names

Toll-like receptor 8; toll like receptor 8; CD288; hIMD98.

Background

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is predominantly expressed in lung and peripheral blood leukocytes, and lies in close proximity to another family member, TLR7, on chromosome X.

Protein class

CD markers

Predicted location

Membrane

Single cell type specificity

Group enriched (Kupffer cells, monocytes, Macrophages)

Immune cell specificity

Group enriched (neutrophil, classical monocyte, non-classical monocyte, intermediate monocyte, myeloid DC)

Cell line specificity

Not detected

Interaction

Homodimer (PubMed:23520111, PubMed:25599397, PubMed:26929371, PubMed:29155428). Interacts with MYD88 via their respective TIR domains (Probable). Interacts with UNC93B1 (By similarity). Interacts with BTK (PubMed:17932028). Interacts with SMPDL3B (By similarity).

Molecular function

Receptor

More Types Infomation

Anti-TLR8 rAb Products

Our anti-TLR8 recombinant antibody products are meticulously engineered to offer superior performance for your research needs. Produced using advanced recombinant technology, these antibodies boast exceptional specificity, high purity, and remarkable batch-to-batch consistency. This ensures reliable and reproducible results across diverse applications, making them an ideal choice for accurate target identification, precise cellular detection, and robust functional assays in immunological studies.

Table 1. Featured anti-TLR8 recombinant antibody products at Creative Biolabs.

Cat. No. Product Name Target Species Host Species Applications
MOB-1646z Mouse Anti-TLR8 Recombinant Antibody (clone 28H8) Human Mouse IgG1, κ WB, FC, ICC, IF, IHC, DB
MOB-2061CT Recombinant Mouse anti-Human TLR8 Monoclonal antibody (55D254) Human Mouse FC, IHC-P, WB

Creative Quality Control

At Creative Biolabs, we implement rigorous, multi-faceted quality control measures to evaluate our anti-TLR8 recombinant antibody products utilizing state-of-the-art analytical techniques. Each batch is extensively validated for specificity, purity, affinity, and biological activity through methods such as SDS-PAGE, SEC-HPLC, ELISA, and functional assays. This stringent approach guarantees uncompromised quality, superior performance, and absolute reliability for our global customers.

Customer Reviews

Excellent
Ke***o
Recombinant Mouse anti-Human TLR8 Monoclonal antibody (55D254) (MOB-2061CT)
Creative Biolabs' anti-TLR8 recombinant antibody revolutionized our study. Its steady performance and great specificity have considerably expedited our research into innate immune responses. The device came quickly, and the technical support staff provided invaluable assistance during our trial design. Highly recommended for any serious immunology laboratory!
12/Oct/2023
Excellent
To***i
Mouse Anti-TLR8 Recombinant Antibody (clone 28H8) (MOB-1646z)
We've incorporated Creative Biolabs' anti-TLR8 antibodies into our preclinical drug screening platform, and the results have been outstanding. The antibody’s high affinity and low background noise are crucial for our sensitive assays, consistently delivering clear, publishable data. It's a reliable and cost-effective solution that has streamlined our workflow considerably.
19/Apr/2024
Excellent
Sh***u
Mouse Anti-TLR8 Recombinant Antibody (clone 28H8) (MOB-1646z)
The versatility of Creative Biolabs’ anti-TLR8 recombinant antibodies across various applications, including Western blot and flow cytometry, is impressive. We've achieved excellent signal-to-noise ratios and consistent data, enabling us to confidently explore TLR8's role in different disease models.
3/Nov/2024

rAb Production

The manufacturing of our anti-TLR8 recombinant antibody products adheres to highly optimized protocols, leveraging cutting-edge recombinant expression platforms, primarily in mammalian cell systems. This meticulous approach ensures the generation of antibodies with correct folding and essential post-translational modifications, which are critical for their biological functionality. Our scalable production capabilities and stringent in-process controls are designed to deliver consistent supply and superior quality, meeting the exacting demands of advanced scientific research and preclinical validation.

Featured Anti-TLR8 Recombinant Antibody Production PlatformsFig.1 Milligram-scale. (Creative Biolabs Original)
Fig.1 Milligram-scale anti-TLR8 recombinant antibody production.

Fig.2 Gram-scale. (Creative Biolabs Original)Fig.2 Gram-scale anti-TLR8 recombinant antibody production.

rAb Modalities

Creative Biolabs offers anti-TLR8 recombinant antibodies in various modalities, including different host species and conjugation options. This versatility ensures that our antibodies can be seamlessly integrated into a wide array of experimental designs and detection platforms.

Fig.3 TLR8 antibody production and modalities. (Creative Biolabs Original)Fig.3 Full-length anti-TLR8 recombinant antibody production and modalities.

TLR8-Targeted Drug Information

Table 2. Public drug targeting TLR8.

Research phase Company Classification Indications Details
Zhejiang University (Originator) Preclinical Cancer Immunotherapy
Liposomes
Monoclonal Antibodies
Cancer, breast
Cancer, solid tumor
Universitaet Bern (Originator) Preclinical Cancer Immunotherapy
Cancer Vaccines
Nanoparticles
Single-stranded oligoribonucleotide (RNA)
Toxins
Virus-Like Particle Vaccines
Cancer
Altimmune (Originator) Preclinical Cancer Immunotherapy
Cancer Vaccines
Peptide Vaccines
Cancer, colorectal
Cancer, solid tumor
Korea University (Originator) Preclinical MicroRNA Atopic dermatitis
Sungkyunkwan University (Originator) Biological Testing Coronavirus Vaccines
Nanoparticles
Polypeptides, from 41 AA
Recombinant proteins
Recombinant Vaccines
Coronavirus acute respiratory syndrome
Sungkyunkwan University (Originator) Biological Testing Cancer Immunotherapy
Cancer Vaccines
Nanoparticles
Peptides
Peptide Vaccines
Cancer
Sichuan University (SCU) (Originator) Biological Testing Cancer Immunotherapy
Cancer Vaccines
Extracellular Vesicles
Vaccine Adjuvants
Cancer, breast
Cero Therapeutics (Originator) Biological Testing Cancer Immunotherapy
Cytotoxic T Lymphocytes (CTLs)
TCR-Modified T Cells
Cancer, head and neck (squamous cell carcinoma)

(Disclaimer: The information in this table is just for knowledge sharing and not for marketing or sales purposes.)

As a trusted leader in antibody development, Creative Biolabs is dedicated to providing high-quality solutions that propel scientific discovery. Our anti-TLR8 recombinant antibody products are a testament to our commitment to innovation and excellence. We invite you to explore how these advanced tools can benefit your research and therapeutic development efforts. For customized solutions or to discuss your specific project needs, please do not hesitate to get in touch with us.

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