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TMIGD2

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For Research Use Only. Not For Clinical Use.


Background

Plays a role in cell-cell interaction, cell migration, and angiogenesis. Through interaction with HHLA2, costimulates T-cells in the context of TCR-mediated activation. Enhances T-cell proliferation and cytokine production via an AKT-dependent signaling cascade.
Predicted location

Intracellular, Membrane (different isoforms)

Single cell type specificity

Group enriched (NK-cells, dendritic cells, T-cells)

Immune cell specificity

Immune cell enhanced (MAIT T-cell)

Cell line specificity

Group enriched (BEWO, HEL, MOLT-4)

Interaction

May form homophilic interactions that could regulate cell-cell interaction. Interacts with CACNB2, DST, MIA and NCKIPSD. Interacts with HHLA2.

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