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TMOD1

This gene encodes a member of the tropomodulin family. The encoded protein is an actin-capping protein that regulates tropomyosin by binding to its N-terminus, inhibiting depolymerization and elongation of the pointed end of actin filaments and thereby influencing the structure of the erythrocyte membrane skeleton. Multiple transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Oct 2009]
Predicted location

Intracellular

Single cell type specificity

Cell type enhanced (Erythroid cells, Horizontal cells, Cardiomyocytes)

Immune cell specificity

Low immune cell specificity

Cell line specificity

Cell line enhanced (EFO-21, HDLM-2, K-562, SH-SY5Y)

Interaction

Binds to the N-terminus of isoforms 2/3 of TPM3 and to actin.

Molecular function

Actin-binding

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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