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TMPRSS6

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For Research Use Only. Not For Clinical Use.


The protein encoded by this gene is a type II transmembrane serine proteinase that is found attached to the cell surface. The encoded protein may be involved in matrix remodeling processes in the liver. Alternative splicing results in multiple transcript variants.
Protein class

Disease related genes, Enzymes, Human disease related genes, Plasma proteins, Potential drug targets

Predicted location

Intracellular, Membrane (different isoforms)

Single cell type specificity

Group enriched (Late spermatids, Hepatocytes, Early spermatids)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Group enriched (Hep G2, SCLC-21H)

Interaction

Interacts with HJV.

Molecular function

Hydrolase, Protease, Serine protease

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