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TNFRSF19

Anti-TNFRSF19 Recombinant Antibody Products

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For Research Use Only. Not For Clinical Use.


The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is highly expressed during embryonic development. It has been shown to interact with TRAF family members, and to activate JNK signaling pathway when overexpressed in cells. This receptor is capable of inducing apoptosis by a caspase-independent mechanism, and it is thought to play an essential role in embryonic development. Alternatively spliced transcript variants encoding distinct isoforms have been described.
Protein class

Plasma proteins

Predicted location

Membrane

Single cell type specificity

Cell type enhanced (Suprabasal keratinocytes, Microglial cells, Respiratory ciliated cells, Basal keratinocytes)

Immune cell specificity

Immune cell enhanced (T-reg)

Cell line specificity

Cell line enhanced (ASC TERT1, BJ hTERT+, fHDF/TERT166, Hep G2, SK-MEL-30, WM-115)

Interaction

Associates with TRAF1, TRAF2, TRAF3 and TRAF5. Interacts with LINGO1.

Molecular function

Receptor

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