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TNFSF8

The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF8/CD30, which is a cell surface antigen and a marker for Hodgkin lymphoma and related hematologic malignancies. The engagement of this cytokine expressed on B cell surface plays an inhibitory role in modulating Ig class switch. This cytokine was shown to enhance cell proliferation of some lymphoma cell lines, while to induce cell death and reduce cell proliferation of other lymphoma cell lines. The pleiotropic biologic activities of this cytokine on different CD30+ lymphoma cell lines may play a pathophysiologic role in Hodgkin's and some non-Hodgkin's lymphomas. Two transcript variants encoding different isoforms have been found for this gene.
Protein class

Cancer-related genes, CD markers

Predicted location

Membrane

Single cell type specificity

Cell type enhanced (T-cells, Plasma cells, Macrophages, B-cells, Kupffer cells, dendritic cells, Microglial cells, monocytes)

Immune cell specificity

Low immune cell specificity

Cell line specificity

Group enriched (Daudi, SuSa, U-698)

Interaction

Homotrimer.

Molecular function

Cytokine

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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