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TNPO3
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- H-2Kd/Fibrosarcoma Tnpo3 (SYMLQALCI) MHC Monomer (MHC-YF204)
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- Class: Class I
- Antigen: Tnpo3
- Antigen Species: Fibrosarcoma
- Peptide: SYMLQALCI
- Conjugate: Biotin
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- H-2Kd/Human TNPO3 (SYMLQALCI) MHC Tetramer (MHC-CN1276)
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- Class: Class I
- Antigen: TNPO3
- Antigen Species: Human
- Peptide: SYMLQALCI
- Conjugate: Unconjugated
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- FITC-H-2Kd/Human TNPO3 (SYMLQALCI) MHC Tetramer (MHC-CN1275)
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- Class: Class I
- Antigen: TNPO3
- Antigen Species: Human
- Peptide: SYMLQALCI
- Conjugate: FITC
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- APC-H-2Kd/Human TNPO3 (SYMLQALCI) MHC Tetramer (MHC-CN1274)
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- Class: Class I
- Antigen: TNPO3
- Antigen Species: Human
- Peptide: SYMLQALCI
- Conjugate: APC
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- PE-H-2Kd/Human TNPO3 (SYMLQALCI) MHC Tetramer (MHC-CN1273)
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- Class: Class I
- Antigen: TNPO3
- Antigen Species: Human
- Peptide: SYMLQALCI
- Conjugate: PE
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- Rabbit Anti-TNPO3 Recombinant Antibody (clone JG38-77) (MRO-1510-CN)
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- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, IF, IHC
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- Anti-TNPO3 Immunohistochemistry Kit (VS-0525-XY7412)
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- Species Reactivity: Human
- Target: TNPO3
- Application: IHC
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For Research Use Only. Not For Clinical Use.
Background
The protein encoded by this gene is a nuclear import receptor for serine/arginine-rich (SR) proteins such as the splicing factors SFRS1 and SFRS2. The encoded protein has also been shown to be involved in HIV-1 infection, apparently through interaction with the HIV-1 capsid protein. Two transcript variants encoding different isoforms as well as a noncoding transcript have been found for this gene.
Protein class
Disease related genes, Human disease related genes
Predicted location
Intracellular
Single cell type specificity
Low cell type specificity
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
Interacts with (GTP-bound) Ran (PubMed:23878195, PubMed:24915079, PubMed:24449914). Interacts with (phosphorylated) SFRS1 and SFRS2; leading to their nuclear import (PubMed:10366588, PubMed:10713112, PubMed:11517331). Interacts with NUP62 (PubMed:11517331, PubMed:24449914). Interacts with RBM4 (PubMed:12628928). Interacts with CPSF6, promoting its nuclear import (PubMed:24449914). (Microbial infection) Interacts with the HIV-1 pre-integration complex (PIC), which is composed of viral genome, matrix protein, Vpr and integrase (PubMed:18722123, PubMed:29329553). Interacts with HIV-1 integrase protein; the interaction is direct (PubMed:29329553).
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