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TP53BP2
Anti-TP53BP2 Recombinant Antibody Products
- Rabbit Anti-TP53BP2 Recombinant Antibody (clone JF09-98) (MRO-0127-CN)
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- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, IF, IHC
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For Research Use Only. Not For Clinical Use.
This gene encodes a member of the ASPP (apoptosis-stimulating protein of p53) family of p53 interacting proteins. The protein contains four ankyrin repeats and an SH3 domain involved in protein-protein interactions. It is localized to the perinuclear region of the cytoplasm, and regulates apoptosis and cell growth through interactions with other regulatory molecules including members of the p53 family. Multiple transcript variants encoding different isoforms have been found for this gene.
Protein class
Cancer-related genes
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Glandular and luminal cells)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
Interacts with P53/TP53; the interaction promotes pro-apoptotic activity (PubMed:11684014, PubMed:8016121, PubMed:12524540). Interacts with BCL2 (PubMed:8668206). Interacts with protein phosphatase 1. Interacts with RELA NF-kappa-B subunit. This interaction probably prevents the activation of apoptosis, possibly by preventing its interaction with TP53. Interacts with APC2 and NAE1. Interacts with DDX42 (via the C-terminus); the interaction is not inhibited by TP53BP2 ubiquitination and is independent of p53/TP53.
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