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TSPAN4
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For Research Use Only. Not For Clinical Use.
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein and is similar in sequence to its family member CD53 antigen. It is known to complex with integrins and other transmembrane 4 superfamily proteins. Alternatively spliced transcript variants encoding different isoforms have been identified.
Predicted location
Membrane
Single cell type specificity
Cell type enhanced (Hofbauer cells, Adipocytes, Leydig cells, Fibroblasts)
Immune cell specificity
Group enriched (classical monocyte, intermediate monocyte, myeloid DC, NK-cell, non-classical monocyte)
Cell line specificity
Low cell line specificity
Interaction
Forms a complex with integrins.
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