TrkA
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Loading...- Mouse Anti-TrkA Antibody (MNAC13), CHO Stable Cell Pool (VS-1025-QX555)
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- Host Species: Mouse
- Target: TrkA
- Species Reactivity: Human
- Antibody Type: Mouse IgG1, κ
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For Research Use Only. Not For Clinical Use.
Background
Neurotrophic receptor tyrosine kinase 1 (NTRK1)is a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation and cancer. Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date.