UBA5

Recombinant Antibody Products

Anti-UBA5 Recombinant Antibody Products

Rabbit Anti-UBA5 Recombinant Antibody (clone DS3743AB) (MOR-3743)
- Derivation: Phage display library
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, ICC, IF, FC, IHC-P
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For Research Use Only. Not For Clinical Use.

This gene encodes a member of the E1-like ubiquitin-activating enzyme family. This protein activates ubiquitin-fold modifier 1, a ubiquitin-like post-translational modifier protein, via the formation of a high-energy thioester bond. Alternative splicing results in multiple transcript variants. A pseudogene of this gene has been identified on chromosome 1.

Protein class

Disease related genes, Human disease related genes

Predicted location

Intracellular, Membrane (different isoforms)

Single cell type specificity

Cell type enhanced (Late spermatids)

Immune cell specificity

Low immune cell specificity

Cell line specificity

Low cell line specificity

Interaction

Homodimer; homodimerization is required for UFM1 activation (PubMed:29295865, PubMed:27653677). Interacts (via UIS motif) with UFM1; binds UFM1 via a trans-binding mechanism in which UFM1 interacts with distinct sites in both subunits of the UBA5 homodimer (PubMed:29295865, PubMed:27653677, PubMed:26929408, PubMed:28360427, PubMed:30412706, PubMed:26872069). Interacts (via UIS motif) with GABARAPL2 and, with lower affinity, with GABARAP and GABARAPL1 (PubMed:26929408, PubMed:30990354). Interacts (via C-terminus) with UFC1 (PubMed:17825256, PubMed:29868776, PubMed:27653677).

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