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UCHL5

Anti-UCHL5 Products

Mouse Anti-UCHL5 Recombinant Antibody (clone 854CT5.5.6) (VS3-QX1217)
- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB
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Mouse Anti-UCHL5 Recombinant Antibody (clone 2D2-H5-A7) (VS3-QX1218)
- Derivation: Mouse
- Species Reactivity: Human, Mouse
- Type: Mouse IgG1
- Application: WB
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Recombinant Rabbit Anti-UCHL5 Antibody (clone R03-9C1) (VS3-FY1521)
- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, ICC, IF, IP
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Rabbit Anti-UCHL5 Recombinant Antibody (clone DS3773AB) (MOR-3773)
- Derivation: Phage display library
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, IHC, IP, FC
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For Research Use Only. Not For Clinical Use.

Background

Protease that specifically cleaves Lys-48-linked polyubiquitin chains. Deubiquitinating enzyme associated with the 19S regulatory subunit of the 26S proteasome. Putative regulatory component of the INO80 complex; however is inactive in the INO80 complex and is activated by a transient interaction of the INO80 complex with the proteasome via ADRM1.

Protein class

Enzymes, Plasma proteins

Predicted location

Intracellular

Single cell type specificity

Low cell type specificity

Immune cell specificity

Low immune cell specificity

Cell line specificity

Low cell line specificity

Interaction

Component of the 19S (PA700) regulatory complex of the 26S proteasome. Interacts with ADRM1 and NFRKB; in vitro ADRM1 and NFRKB compete for interaction with UCHL5. Component of the INO80 complex; specifically part of a complex module associated with N-terminus of INO80.

Molecular function

Hydrolase, Protease, Thiol protease

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