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UGT2B17

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For Research Use Only. Not For Clinical Use.


Background

This gene encodes a member of the uridine diphosphoglucuronosyltransferase protein family. The encoded enzyme catalyzes the transfer of glucuronic acid from uridine diphosphoglucuronic acid to a diverse array of substrates including steroid hormones and lipid-soluble drugs. This process, known as glucuronidation, is an intermediate step in the metabolism of steroids. Copy number variation in this gene is associated with susceptibility to osteoporosis.
Protein class

Enzymes, Human disease related genes, Metabolic proteins

Predicted location

Membrane

Single cell type specificity

Group enriched (Distal enterocytes, Undifferentiated cells, Paneth cells)

Immune cell specificity

Group enriched (naive B-cell, memory B-cell)

Cell line specificity

Cell line enhanced (BEWO, NB-4, RPMI-8226)

Molecular function

Glycosyltransferase, Transferase

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